Molecular Biology-מעבדה רפואית

Which of the following protein domains or motifs are found in eukaryotic transcription factor DNA binding or activation domains.

1

שאלה #39152

		All of these may be.
		poly Glutamine
		poly Proline
		leucine zipper
		Homeodomain
		Zinc finger

מיין לפי

(USMLoid) Sequencing the factor IX gene of a 12-year old hemophilia patient shows a T->G point mutation 20 base-pairs before the first exon of the gene. This is most likely to disrupt the binding of which of the following?

1

שאלה #39153

		Transcription factor
		Histone
		DNA polymerase
		snRNP
		The mRNA 5'-CAP binding protein

מיין לפי

TBP, the TATA Binding Protein:

1

שאלה #39154

		is often needed for the initiation of transcription in eukaryotes
		is always needed for the initiation of translation in eukaryotes
		binds to the sequence TATA of prokaryotic promoters
		is sometimes needed for the initiation of transcription in prokaryotes
		is part of the prokaryotic RNA polymerase holoenzyme
		is part of the eukaryotic ribosome
		binds to the Kozak sequence
		is part of the eukaryotic transcription initiation complex

מיין לפי

(USMLoid) The protein encoded the gene ZEB1 was discovered to induce genes causing an Epithelial Mesenchymal Transition (EMT) during breast cancer tumor progression. The gene sequence and protein X-ray crystallography data showed that ZEB1 encodes a Zinc-finger motif. Which of the following is a most likely characteristic of the ZEB1 protein.

1

שאלה #39155

		protein phosphorylation
		proteoglycan binding
		ion transport across the plasma membrane
		GTP hydrolysis
		Sequence-specific DNA binding

מיין לפי

Neurons, after they are first born, slowly start to express a neurofilament gene (NF-L) for the first time. The promoter of the NF-L gene is rich in CpG sequences. Which of the following would you expect to observe in the NF-L promoter as the gene becomes increasingly active in neurons?

1

שאלה #39156

		Increased recruitment of histone deacetylase (HDAC) to the promoter, leading to heterochromatinization of the NF-L gene.
		Loss of methylation of C in sequences other than CpG.
		Loss of methylation of C in the sequence CpG.
		Increased recruitment of histone deacetylase (HDAC) to the promoter, leading to a decrease in the methylation of C in sequences other than CpG.
		Increased binding of Repressor proteins to the NF-L promoter, leading to increased methylation of C in the sequence CpG.

מיין לפי

(USMLoid) Albumin is produced in the liver. Which of the following enzymes is more likely to act on the albumin gene in isolated hepatocyte nuclei compared to the same gene in isolated astrocyte nuclei.

1

שאלה #39157

		ligase
		DNase I (Randomly cleaves phosphodiester bonds in DNA)
		RNase (Randomly cleaves phospodiester bonds in RNA)
		Reverse transcriptase
		peptidyl transferase

מיין לפי

Esti Gerbi 0 נקודות · יותר מ-6 חודשים

מוניטין: 1

למה DNase זו תשובה לא נכונה? מה התשובה הנכונה?

Tevel Bruckner 0 נקודות · יותר מ-6 חודשים

מוניטין: 45

טעות. DNase התשובה.

USMLoid) In mammalian genomic DNA, methylation of C at position 5 of the pyrimidine sometimes occurs in the dinucleotide CpG. These sequences are unusually susceptible to mutation. Which of the following is the reason? ב-DNA גנומי של יונקים, מתרחשת לעיתים מתילציה בעמדה מס' 5 של הפרימידין C, כאשר הוא מופיע בקונטקסט CpG. רצפים אלו רגישים באופן יוצא דופן ליצירת מוטציות. מי מהבאים היא הסיבה?

1

שאלה #39158

		5mC interferes with progression of the DNA replication fork Cm5 מפריע להתקדמות מזלג השכפול
		Methylated DNA is more exposed to exogenous mutagens DNA שעבר מתילציה חשוף יותר לחומרים מוטגנים שמקורם מחוץ לגוף
		Methylated DNA is more frequently subjected to homologous recombination. DNA שעבר מתילציה יעבור בתדירות גבוהה יותר רקומבינציה הומולוגית
		5mC reduces the strength of hydrogen bonding with its complement on the other DNA strand. Cm5 מוריד את חוזק קשרי המימן שלו עם הנוקלאוטיד המשלים לו בגדיל השני.
		5mC may be converted to T by deamination Cm5 עשוי להפוך ל-T בעקבות דה-אמינציה

מיין לפי

It is the day after Rosh Hashana. You have been sitting on the beach for 2.4 hours and are currently trying to decide whether to have another slice of watermelon or go swimming. Which of the following intervals contains the number of potentially mutagenic events each genome in your body has suffered since you got to the beach?

1

שאלה #39159

		0.03 - 3
		30,000 - 3,000,000
		3-300
		300 - 30,000

מיין לפי

Which of the following DNA repair mechanisms is directly coupled to the transcription machinery.

1

שאלה #39160

		Nucleotide Excision Repair
		Mismatch Repair
		Base Excision Repair
		. Nonhomologous End Joining

מיין לפי

Ran Unikel 0 נקודות · יותר מ-6 חודשים

מוניטין: 45

שאלה ה ז ו י ה!!!!!!!!1

Which of the following repair pathways is most likely to result in an imperfect repair? מי ממסלולי התיקון הבאים עשוי לגרום קרוב לוודאי לתיקון לא מושלם?

1

שאלה #39161

		Photolyase
		Mismatch repair
		Homologous Recombination
		Nucleotide Excision Repair
		Non-homologous End Joining

מיין לפי

Molecular Biology-מעבדה רפואית

Discuss, Learn and be Happy דיון בשאלות

Which of the following protein domains or motifs are found in eukaryotic transcription factor DNA binding or activation domains.

(USMLoid) Sequencing the factor IX gene of a 12-year old hemophilia patient shows a T->G point mutation 20 base-pairs before the first exon of the gene. This is most likely to disrupt the binding of which of the following?

TBP, the TATA Binding Protein:

Neurons, after they are first born, slowly start to express a neurofilament gene (NF-L) for the first time. The promoter of the NF-L gene is rich in CpG sequences. Which of the following would you expect to observe in the NF-L promoter as the gene becomes increasingly active in neurons?

(USMLoid) Albumin is produced in the liver. Which of the following enzymes is more likely to act on the albumin gene in isolated hepatocyte nuclei compared to the same gene in isolated astrocyte nuclei.

Which of the following DNA repair mechanisms is directly coupled to the transcription machinery.

Which of the following repair pathways is most likely to result in an imperfect repair? מי ממסלולי התיקון הבאים עשוי לגרום קרוב לוודאי לתיקון לא מושלם?

בקשה לשינוי התשובה / תיקון שאלה gavel

בקשה למחיקת השאלהmood_bad

בקשה לשינוי התשובה / תיקון שאלה

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