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Complete the following sentence. The covalent bond between a tRNA and its amino acid is catalysed: השלם את המשפט הבא: הקישור הקוולנטי בין tRNA והחומצה האמינית אליה המתאימה, מזורז -

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(USMLoid) You have identified a mutation in a gene transcribed in the liver. At codon 42 of the expected translation product you find 5'-CAT-3' instead of the normal codon 5'-GAT-3'. This same mutation is found associated with type II diabetes in a large kindred. Which of the following best describes the effect of this change on the protein encoded?

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This is a small gene with some features labeled. Which of the following will mostly likely result from a 2 nt deletion at the site of mutation?

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Look at the genetic code included with the exam. What is the minimum possible number of different tRNAs to be charged with Serine?

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The following piece of DNA codes for an mRNA. The top strand is the template strand. The initiation and terminations codons are in the sequence. 5'-AATTACCATGAAATTGTCATCTACTTGTTGATTA-3' 3'-TTAATGGTACTTTAACAGTAGATGAACAACTAAT-5 The sequence of the protein encoded by this transcript is:

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Which best fits the process of translation? איזה מן האיורים מתאים ביותר לתהליך התרגום?

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(USMLoid) The single tyrosine tRNA recognises both of the tyrosine codons - UAU and UAC. Which of the following is therefore the anticodon sequence of this tRNA? את שני הקודונים עבור טירוזין – UAU, UAC – מזהה tRNA יחיד. אם כך, מי מהבאים הינו רצף האנטי-קודון של tRNA זה?

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This is a question about the wobble position - and yes, it corresponds almost exactly to a USMLE question. However, you can answer it without remembering almost anything about that table of non-canonical base-pairings at the wobble position. Just think it through. All the choices except the correct one are eliminated even if you just remember that a base never base-pairs with itself. The correct answer is: 5' - GUA - 3'
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CCATACACACCCC GTGGTGAGAGGAC AACTTGTCTACAG GTTATAACAGTCT CGTTCGGCACAGG TCATTGACCTTTT ACCTTGACACAGA TAGTCGATACGCA ATATTGGCAAGGA These are nine sequences from the -35 regions of 9 typical prokaryotic promoters. Which one is most likely to contain the -35 concensus sequence?

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In eukaryotes the ribosomal RNAs are transcribed by הRNA – הרובוזומלי באאוקריוטים מתועתק על ידי:

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(USMLoid) Which activity is associated with E.coli σ (sigma) during transcription? על איזו פעילות אחראית היחידה סיגמא בחיידקי E.Coli במהלך תעתוק:

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