Molecular Biology Module 6: DNA damage and repair

Which of the following repair pathways is most likely to result in an imperfect repair?

1

מיין לפי

During S-phase in a human cell, the entire genome (approximately 6x109 bp) is copied. The enzymes that copy the DNA are not perfect. As they polymerise the new strands they add the wrong nucleotide approximately 200,000 times. Most of these are fixed, but the fixing is not perfect either. A mistake that is not fixed becomes a mutation. Which of the following is closest to the number of mutations that arise during replication of the human genome?

1

מיין לפי

(USMLoid) Which of the following is the most frequent DNA damage induced by ultraviolet light?

1

מיין לפי

Which repair mechanism is most likely to repair the DNA damage shown?

1

מיין לפי

Which repair mechanism is most likely to repair the DNA damage shown? given the pic above

1

מיין לפי

(USMLoid) In mammalian genomic DNA, methylation of C at position 5 of the pyrimidine sometimes occurs in the dinucleotide CpG. These sequences are unusually susceptible to mutation. Which of the following is the reason?

1

מיין לפי

During DNA replication, C sits on the template strand in the active site of the polymerase. An A is accidentally added to the 3' end of the new strand being synthesized. Which of the following repair functions will most likely remove it?

1

מיין לפי

(USMLoid) A 55 year old woman comes to the clinic complaining of fatigue. Physical examination shows no abnormalities. A test for occult blood in the stool is positive. Her hematocrit is 30%. Her family history indicates that her mother her maternal grandfather, and a maternal aunt all died of colon cancer, each before the age of 60. Colonoscopy showed a mass in the proximal colon and a subsequent biopsy identified mucinous carcinoma. Karyotypes were normal. In which genes encoding components of the following functions is she most likely to bear an inherited mutation?

1

מיין לפי

Which of the following DNA repair mechanisms is directly coupled to the transcription machinery. Which of the following DNA repair mechanisms is directly coupled to the transcription machinery.

1

מיין לפי

Molecular Biology Module 6: DNA damage and repair

Discuss, Learn and be Happy דיון בשאלות

Which of the following repair pathways is most likely to result in an imperfect repair?

(USMLoid) Which of the following is the most frequent DNA damage induced by ultraviolet light?

Which repair mechanism is most likely to repair the DNA damage shown?

Which repair mechanism is most likely to repair the DNA damage shown? given the pic above

(USMLoid) In mammalian genomic DNA, methylation of C at position 5 of the pyrimidine sometimes occurs in the dinucleotide CpG. These sequences are unusually susceptible to mutation. Which of the following is the reason?

During DNA replication, C sits on the template strand in the active site of the polymerase. An A is accidentally added to the 3' end of the new strand being synthesized. Which of the following repair functions will most likely remove it?

Which of the following DNA repair mechanisms is directly coupled to the transcription machinery. Which of the following DNA repair mechanisms is directly coupled to the transcription machinery.