שאלה | Which scenario would require the use of Polygenic Risk Scores (PRS) rather than a Genome-Wide Association Study (GWAS)?

Which scenario would require the use of Polygenic Risk Scores (PRS) rather than a Genome-Wide Association Study (GWAS)?

		Identifying new genetic variants linked to Type 2 Diabetes in a population
		Studying how a specific SNP influences multiple diseases, such as diabetes, obesity, and cardiovascular disease
		Investigating the causal impact of increased BMI on hypertension risk using genetic variants as natural experiments
		Calculating an individual's genetic predisposition to heart disease by aggregating the effects of multiple known genetic variants