שאלה | (USMLoid) You have identified a mutation in a gene transcribed in the liver. At codon 42 of the expected translation product you find 5'-CAT-3' instead of the normal codon 5'-GAT-3'. This same mutation is found associated with type II diabetes in a large kindred. Which of the following best describes the effect of this change on the protein encoded?

(USMLoid) You have identified a mutation in a gene transcribed in the liver. At codon 42 of the expected translation product you find 5'-CAT-3' instead of the normal codon 5'-GAT-3'. This same mutation is found associated with type II diabetes in a large kindred. Which of the following best describes the effect of this change on the protein encoded?

		1. Val ---> Leu
		2. His ---> Asp
		3. Asp ---> His
		4. Leu ---> Val
		5. Addition of amino acid sequence beyond the normal carboxy terminus

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