(USMLoid) The VHL gene is often mutated in people suffering from von Hippel-Lindau (VHL) disease. The VHL protein is found in a ubiquitin-ligase complex that targets the transcription factor Hypoxia Inducible Factor 1 (HIF-1). In VHL patients HIF-1 is not targeted for destruction by the ubiquitination pathway. Which of the following genes will most likely show increased gene expression as a result?
ביולוגיה מולקולרית Molecular Biology Module 5: Gene Regulation
(USMLoid) The VHL gene is often mutated in people suffering from von Hippel-Lindau (VHL) disease. The VHL protein is found in a ubiquitin-ligase complex that targets the transcription factor Hypoxia Inducible Factor 1 (HIF-1). In VHL patients HIF-1 is not targeted for destruction by the ubiquitination pathway. Which of the following genes will most likely show increased gene expression as a result?
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The key to answering this question is not to remember the pathways, but simply to build the sensible association between hypoxia and a need for more blood vessels. That leads you directly to the VEGF receptor. That simple.
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* השאלה נוספה בתאריך: 28-01-2021